Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome:
A Systematic Review and Meta-analysis, with a Plain Language Summary.
Michael C. Ferraro, BSc(Hons); Neil E. O’Connell, PhD; Andreas Goebel, MD, PhD; Ruaraidh Hill, PhD;
Ffion Curtis, PhD; Jack Wilkinson, PhD; Jacqueline R. Center, MBBS, MS, PhD; Sylvia M. Gustin, PhD;
Aidan G. Cashin, PhD*; and
James H. McAuley, PhD*

Bisphosphonates_for_CRPS_with_Plain_Language_Summary

“What did we do?
We searched for randomised controlled trials that compared any bisphosphonate with a
placebo (“dummy” medicine). We compared and summarised the trial results and rated our
confidence in the evidence, based on factors such as trial methods and sizes.”